Heat exchanger networks present an interesting control problem due to coupling among process streams. In this work, the linear quadratic regulator (LQR), a feedback optimal control technique, is used to control stream temperatures on a laboratory scale heat exchanger network, through bypass manipulation, in a multivariable system. The LQR design was based on a mathematical model of the plant and its performance was compared to traditional PID control and to dynamical decoupling. Experimental tests were performed to evaluate the controllers, involving regulatory and servo problems. The performance of the different controllers was quantitatively compared by using the integral absolute error. Although LQR is not a new control methodology, the results obtained in this work suggest that LQR is an interesting alternative to control HEN when compared to the PID and to the dynamic decoupler. Moreover, one of the main advantages of the LQR is its tuning simplicity, since only one parameter is sufficient for this application.