دورية أكاديمية

Oocytes, embryos and pluripotent stem cells from a biomedical perspective

التفاصيل البيبلوغرافية
العنوان: Oocytes, embryos and pluripotent stem cells from a biomedical perspective
المؤلفون: Hyttel, Poul, Pessôa, Laís Vicari de Figueiredo, Secher, Jan Bojsen-Møller, Dittlau, Katarina Stoklund, Freude, Kristine, Hall, Vanessa J, Fair, Trudee, Assey, Remmy John, Laurincik, Jozef, Callesen, Henrik, Greve, Torben, Stroebech, Lotte Björg
المصدر: Animal Reproduction. September 2019 16(3)
بيانات النشر: Colégio Brasileiro de Reprodução Animal, 2019.
سنة النشر: 2019
مصطلحات موضوعية: embryonic stem cells, induced pluripotent stem cells, in vitro fertilization, Alzheimer’s disease, dementia
الوصف: The veterinary and animal science professions are rapidly developing and their inherent and historical connection to agriculture is challenged by more biomedical and medical directions of research. While some consider this development as a risk of losing identity, it may also be seen as an opportunity for developing further and more sophisticated competences that may ultimately feed back to veterinary and animal science in a synergistic way. The present review describes how agriculture-related studies on bovine in vitro embryo production through studies of putative bovine and porcine embryonic stem cells led the way to more sophisticated studies of human induced pluripotent stem cells (iPSCs) using e.g. gene editing for modeling of neurodegeneration in man. However, instead of being a blind diversion from veterinary and animal science into medicine, these advanced studies of human iPSC-derived neurons build a set of competences that allowed us, in a more competent way, to focus on novel aspects of more veterinary and agricultural relevance in the form of porcine and canine iPSCs. These types of animal stem cells are of biomedical importance for modeling of iPSC-based therapy in man, but in particular the canine iPSCs are also important for understanding and modeling canine diseases, as e.g. canine cognitive dysfunction, for the benefit and therapy of dogs.
نوع الوثيقة: article
وصف الملف: text/html
اللغة: English
تدمد: 1984-3143
DOI: 10.21451/1984-3143-ar2019-0054
URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-31432019000300508
حقوق: info:eu-repo/semantics/openAccess
رقم الأكسشن: edssci.S1984.31432019000300508
قاعدة البيانات: SciELO
الوصف
تدمد:19843143
DOI:10.21451/1984-3143-ar2019-0054