Design and synthesis of HIV-1 protease inhibitors.: Novel tetrahydrofuran P2/P2 '-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex
التفاصيل البيبلوغرافية
العنوان:
Design and synthesis of HIV-1 protease inhibitors.: Novel tetrahydrofuran P2/P2 '-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex
A series of HIV-1 protease inhibitors having new tetrahydrofuran P2/P2' groups have been synthesised and tested for protease inhibition and antiviral activity. Six novel 4-aminotetrahydrofuran derivatives were prepared starting from commercially available isopropylidene-alpha-D-xylofuranose yielding six symmetrical and six unsymmetrical inhibitors. Promising sub nanomolar HIV-1 protease inhibitory activities were obtained. The X-ray crystal structure of the most potent inhibitor (23, K-i 0.25 nM) cocrystallised with HIV-1 protease is discussed and the binding compared with inhibitors 1a and 1b.
