Discovery of sulfonamide resistance genes in deep groundwater below Patna, India
| العنوان: | Discovery of sulfonamide resistance genes in deep groundwater below Patna, India |
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| المؤلفون: | Wilson, George J. L., Perez-Zabaleta, Mariel, 1987, Owusu-Agyeman, Isaac, Kumar, Arun, Ghosh, Ashok, Polya, David A., Gooddy, Daren C., Cetecioglu, Zeynep, PhD, 1981, Richards, Laura A. |
| المصدر: | Environmental Pollution. 356 |
| مصطلحات موضوعية: | Antimicrobial resistance genes, Sulfonamides, Water contamination, Rapidly developing city, Wastewater |
| الوصف: | Global usage of pharmaceuticals has led to the proliferation of bacteria that are resistant to antimicrobial treatments, creating a substantial public health challenge. Here, we investigate the emergence of sulfonamide resistance genes in groundwater and surface water in Patna, a rapidly developing city in Bihar, India. We report the first quantification of three sulfonamide resistance genes (sulI, sulII and sulIII) in groundwater (12-107 m in depth) in India. The mean relative abundance of gene copies was found to be sulI (2.4 x 10(-2) copies/16S rRNA gene) > sulII (5.4 x 10(-3) copies/16S rRNA gene) > sulIII (2.4 x 10(-3) copies/16S rRNA gene) in groundwater (n = 15) and surface water (n = 3). A comparison between antimicrobial resistance (AMR) genes and wastewater indicators, particularly tryptophan:fulvic-like fluorescence, suggests that wastewater was associated with AMR gene prevalence. Urban drainage channels, containing hospital and domestic wastes, are likely a substantial source of antimicrobial resistance in groundwater and surface water, including the Ganges (Ganga) River. This study is a reference point for decision-makers in the fight against antimicrobial resistance because it quantifies and determines potential sources of AMR genes in Indian groundwater. |
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| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-350157 https://doi.org/10.1016/j.envpol.2024.124205 |
| قاعدة البيانات: | SwePub |
| تدمد: | 02697491 18736424 |
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| DOI: | 10.1016/j.envpol.2024.124205 |