Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis.
| العنوان: | Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis. |
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| المؤلفون: | Sigurdardottir, Gunnthorunn, Ekman, Anna-Karin, Ståhle, Mona, Bivik, Cecilia, Enerbäck, Charlotta |
| المصدر: | The Journal of American Academy of Dermatology. 70(6):1067-1075 |
| الوصف: | BACKGROUND: Psoriasis is associated with a systemic inflammation and an increased frequency of the metabolic syndrome, both of which are believed to link psoriasis to an increased risk of cardiovascular disease.OBJECTIVE: The study aimed to investigate the systemic expression of markers of cardiovascular risk and determine their response to ultraviolet B therapy and treatment with the tumor necrosis factor-alfa inhibitor, etanercept.METHODS: Six markers of cardiovascular risk were measured in 28 patients with psoriasis and 28 control subjects.RESULTS: Five of the 6 investigated markers were elevated in patients with psoriasis. Four of these correlated to the body mass index and waist-hip ratio, suggesting a link to the metabolic syndrome. Total plasminogen activator inhibitor-1 remained elevated independently of these factors. The levels of the investigated risk markers decreased considerably after tumor necrosis factor-alfa inhibitor treatment but remained unaffected by ultraviolet therapy.LIMITATIONS: A relatively limited study population and nonrandomization are limitations.CONCLUSION: These findings suggest that the choice of treatment in psoriasis may influence the cardiovascular risk in patients with psoriasis and the metabolic syndrome. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-107732 https://liu.diva-portal.org/smash/get/diva2:727108/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
Full Text via ClinicalKey | تدمد: | 01909622 10976787 |
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| DOI: | 10.1016/j.jaad.2013.12.044 |