Duodenal lymphogram as a complementary tool in the diagnosis of celiac disease in adults
| العنوان: | Duodenal lymphogram as a complementary tool in the diagnosis of celiac disease in adults |
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| المؤلفون: | Burgueno, Beatriz, Escudero-Hernández, Celia, de Pedro, Rodrigo, Montalvillo, Enrique, Bernardo, David, Garcia Lagarto, Elena, Garrote Adrados, Jose Antonio, Arranz Sanz, Eduardo, Fernandez-Salazar, Luis |
| المصدر: | Revista española de enfermedades digestivas. 112(6):434-439 |
| مصطلحات موضوعية: | Lymphogram, Flow cytometry, Celiac disease |
| الوصف: | Introduction: celiac disease (CD) patients have a specific pattern of lymphocytic infiltrate in the duodenal mucosa. Flow cytometry is a complementary tool for the diagnosis of CD, which allows the quantification and characterization of intraepithelial lymphocytes (IELs) by what is commonly called a lymphogram. Here we describe our experience with this technique in the diagnosis of CD in adult patients. Methods: lymphograms from 157 patients performed in our center between 2009 and 2017 were retrospectively analyzed. Fourteen patients had a previous diagnosis of CD and followed a gluten-free diet (GFD), 21 had a new diagnosis of CD and the remaining were considered as non-celiac. The association of the lymphogram results (total IELs, CD3- lymphocytes and TcR gamma delta lymphocytes) with the CD diagnosis, compliance with the GFD, time since diagnosis and IgA anti-TG2 titer were determined. Results: the area under the ROC curve of TcR gamma delta lymphocytes for CD patients varied between 0.86 and 0.86. The percentage of TcR gamma delta lymphocytes in GFD-treated patients was lower; 12 (8.5) vs 20.5 (8.7), p = 0.0153. However, it remained high compared to non-CD; 12 (8.5) vs 6.7 (6), p = 0.135. The time since diagnosis and IgA anti-TG2 titer correlated with the lymphogram results. Helicobacter pylori infection and treatment with angiotensin receptor antagonist 2 (ARA2) were associated with differences in the lymphogram results in patients without CD. Conclusions: the duodenal lymphogram is a reliable complementary tool in adults for the diagnosis of CD. However, compliance and duration of the GFD and other factors may condition its diagnostic capacity. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167319 https://liu.diva-portal.org/smash/get/diva2:1450981/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 11300108 23404167 |
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| DOI: | 10.17235/reed.2020.6391/2019 |