Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months Post-Partum on Child Allergic Disease Outcomes

التفاصيل البيبلوغرافية
العنوان: Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months Post-Partum on Child Allergic Disease Outcomes
المؤلفون: Palmer, Debra J., Keelan, Jeffrey, Garssen, Johan, Simmer, Karen, Jenmalm, Maria, Srinivasjois, Ravisha, Silva, Desiree, Prescott, Susan L.
المصدر: Nutrients. 14(13)
مصطلحات موضوعية: allergy prevention, allergen sensitisation, eczema, infancy, lactation, maternal supplementation, prebiotics, pregnancy
الوصف: Infant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects. In pregnancy, the immunomodulatory effects of prebiotics may also have benefits for the developing fetal immune system, and provide a potential dietary strategy to reduce the risk of allergic disease. Here, we present the study protocol for a double-blinded, randomised controlled trial investigating the effects of maternal prebiotics supplementation on child allergic disease outcomes. Eligible pregnant women have infants with a first-degree relative with a history of medically diagnosed allergic disease. Consented women are randomised to consume either prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) or placebo (maltodextrin) powder daily from 18-20 weeks gestation to six months post-partum. The target sample size is 652 women. The primary outcome is infant medically diagnosed eczema; secondary outcomes include allergen sensitisation, food allergies and recurrent wheeze. Breast milk, stool and blood samples are collected at multiple timepoints for further analysis.
وصف الملف: electronic
URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187472
https://liu.diva-portal.org/smash/get/diva2:1689918/FULLTEXT01.pdf
قاعدة البيانات: SwePub
الوصف
تدمد:20726643
DOI:10.3390/nu14132753