Genome-wide DNA Methylation Profiling in Lyme Neuroborreliosis Reveals Altered Methylation Patterns of HLA Genes
| العنوان: | Genome-wide DNA Methylation Profiling in Lyme Neuroborreliosis Reveals Altered Methylation Patterns of HLA Genes |
|---|---|
| المؤلفون: | Henningsson, Anna J., 1972, Hellberg, Sandra, Lerm, Maria, Sayyab, Shumaila |
| المصدر: | Journal of Infectious Diseases. 229(4):1209-1214 |
| مصطلحات موضوعية: | Lyme neuroborreliosis, Borrelia burgdorferi, DNA methylation, Illumina Infinium methylation EPIC 850K, HLA |
| الوصف: | Lyme neuroborreliosis (LNB) is a complex neuroinflammatory disorder caused by Borrelia burgdorferi, which is transmitted through tick bites. Epigenetic alterations, specifically DNA methylation (DNAm), could play a role in the host immune response during infection. In this study, we present the first genome-wide analysis of DNAm in peripheral blood mononuclear cells from patients with LNB and those without LNB. Using a network-based approach, we highlighted HLA genes at the core of these DNAm changes, which were found to be enriched in immune-related pathways. These findings shed light on the role of epigenetic modifications in the LNB pathogenesis that should be confirmed and further expanded upon in future studies. We present the first genome-wide analysis of DNA methylation in peripheral blood mononuclear cells from patients with and those without the tick-borne infection Lyme neuroborreliosis (LNB). Our findings show that LNB is associated with immune-related DNA methylation changes. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-199130 https://doi.org/10.1093/infdis/jiad451 https://liu.diva-portal.org/smash/get/diva2:1811660/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 00221899 15376613 |
|---|---|
| DOI: | 10.1093/infdis/jiad451 |