CXCL13 in laboratory diagnosis of Lyme neuroborreliosis-the performance of the recomBead and ReaScan CXCL13 assays in human cerebrospinal fluid samples
| العنوان: | CXCL13 in laboratory diagnosis of Lyme neuroborreliosis-the performance of the recomBead and ReaScan CXCL13 assays in human cerebrospinal fluid samples |
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| المؤلفون: | Haglund, Sofie, Lager, Malin, Gyllemark, Paula, Andersson, Gärda, Ekelund, Oskar, Sundqvist, Martin, 1974, Henningsson, Anna J. |
| المصدر: | European Journal of Clinical Microbiology and Infectious Diseases. 41(1):175-179 |
| مصطلحات موضوعية: | CXCL13, Diagnostics, Lyme neuroborreliosis, ReaScan, recomBead |
| الوصف: | The chemokine CXCL13 is used as complement to serology in the diagnostics of Lyme neuroborreliosis (LNB). We evaluated and compared the semi-quantitative, cassette-based ReaScan CXCL13 assay with the quantitative recomBead CXCL13 assay using a collection of 209 cerebrospinal fluid samples. The categorical agreement between results interpreted as negative, grey zone, and positive by the two methods was 87%. The diagnostic sensitivity was higher using the recomBead assay, whereas specificity was higher using ReaScan. Few manual steps, and a short turn-around time with no batching of samples makes the ReaScan CXCL13 assay an attractive complement to serology in the diagnostics of LNB. |
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| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94879 https://doi.org/10.1007/s10096-021-04350-y |
| قاعدة البيانات: | SwePub |
Find this article in full text from Springer Verlag. | تدمد: | 09349723 14354373 |
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| DOI: | 10.1007/s10096-021-04350-y |