Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
| العنوان: | Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling |
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| المؤلفون: | Abdullah Nasir, Ahmad, Herdenberg, Carl, Hedman, Håkan |
| المصدر: | Scientific Reports. 11(1) |
| الوصف: | Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis. Despite extensive efforts, the molecular mechanisms behind many of the physiological functions of netrin-1 have remained elusive. Here, we show that netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling in various cellular systems, including a mutually inhibitory interaction with the BMP-promoting function of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins. The BMP inhibitory function of netrin-1 in mouse embryonic fibroblasts was dependent on the netrin receptor neogenin, with the expression level regulated by both netrin-1 and LRIG proteins. Our results reveal a previously unrecognized function of netrin-1 that may help to explain several of the developmental, physiological, and cancer-promoting functions of netrins at the signal transduction level. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182911 https://doi.org/10.1038/s41598-021-87949-7 https://umu.diva-portal.org/smash/get/diva2:1558198/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-87949-7 |