Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
| العنوان: | Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts |
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| المؤلفون: | Demnitz, Naiara, Hulme, Oliver J., Siebner, Hartwig R., Kjaer, Michael, Ebmeier, Klaus P., Boraxbekk, Carl-Johan, 1980, Gillan, Claire M. |
| المصدر: | Neurobiology of Aging. 131:115-123 |
| مصطلحات موضوعية: | Magnetic resonance imaging (MRI), Modifiable lifestyle factors, Old age, White matter hyperintensities |
| الوصف: | Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214977 https://doi.org/10.1016/j.neurobiolaging.2023.07.023 https://umu.diva-portal.org/smash/get/diva2:1805009/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| DOI: | 10.1016/j.neurobiolaging.2023.07.023 |
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