Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren's contracture
| العنوان: | Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren's contracture |
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| المؤلفون: | Peimer, C A, Wilbrand, Stephan, Gerber, R A, Chapman, D, Szczypa, P P |
| المصدر: | Journal of Hand Surgery, European Volume. 40(2):141-149 |
| الوصف: | Safety was evaluated for collagenase Clostridium histolyticum (CCH) based on 11 clinical trials (N = 1082) and compared with fasciectomy data in a structured literature review of 48 European studies (N = 7727) for treatment of Dupuytren's contracture. Incidence of adverse events was numerically lower with CCH vs. equivalent complications from fasciectomy (median [range] incidence), including nerve injury (0% vs. 3.8% [0%-50+%]), neurapraxia (4.4% vs. 9.4% [0%-51.3%]), complex regional pain syndrome (0.1% vs. 4.5% [1.3%-18.5%]) and arterial injury (0% vs. 5.5% [0.8%-16.5%]). Tendon injury (0.3% vs. 0.1% [0%-0.2%]), skin injury (16.2% vs. 2.8% [0%-25.9%]) and haematoma (77.7% vs. 2.0% [0%-25%]) occurred at a numerically higher incidence with CCH than surgery. Adverse events in CCH trials not reported after fasciectomy included peripheral oedema; extremity pain; injection site pain, haemorrhage and swelling; tenderness; pruritus and lymphadenopathy. CCH-related adverse events were reported as predominantly injection-related and transient. These results may support clinical decision-making for treatment of Dupuytren's contracture. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231912 https://uu.diva-portal.org/smash/get/diva2:746187/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 17531934 20436289 |
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| DOI: | 10.1177/1753193414528843 |