A Nested Case-Control Study on the Risk of Surgical Site Infection After Thyroid Surgery
| العنوان: | A Nested Case-Control Study on the Risk of Surgical Site Infection After Thyroid Surgery |
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| المؤلفون: | Salem, F. A., Almquist, M., Nordenström, E., Dahlberg, J., Hessman, Ola, Lundgren, C. I., Bergenfelz, A. |
| المصدر: | World Journal of Surgery. 42(8):2454-2461 |
| الوصف: | It is unclear if antibiotic prophylaxis reduces the risk of surgical site infection (SSI) in thyroid surgery. This study assessed risk factors for SSI and antibiotic prophylaxis in subgroups of patients. A nested case-control study on patients registered in the Swedish National Register for Endocrine Surgery was performed. Patients with SSI were matched 1:1 by age and gender to controls. Additional information on patients with SSI and controls was queried from attending surgeons using a questionnaire. Risk factors for SSI were evaluated by logistic regression analysis and presented as odds ratio (OR) with 95% confidence interval (CI). There were 9494 operations; 109 (1.2%) patients had SSI. Patients with SSI were older (median 53 vs. 49 years) than patients without SSI p = 0.01 and more often had a cancer diagnosis 23 (21.1%) versus 1137 (12.1%) p = 0.01. In the analysis of patients with SSI versus controls, patients with SSI more often had post-operative drainage 68 (62.4%) versus 46 (42.2%) p = 0.01 and lymph node surgery 40 (36.7%) versus 14 (13.0%) p < 0.01, and both were independent risk factors for SSI, drain OR 1.82 (CI 1.04-3.18) and lymph node dissection, OR 3.22 (95% CI 1.32-7.82). A higher number of 26(62%) patients with independent risk factors for SSI and diagnosed with SSI did not receive antibiotic prophylaxis. Data were missing for 8 (31%) patients. Lymph node dissection and drain are independent risk factors for SSI after thyroidectomy. Antibiotic prophylaxis might be considered in patients with these risk factors. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361043 https://doi.org/10.1007/s00268-018-4492-2 https://uu.diva-portal.org/smash/get/diva2:1249820/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
Find this article in full text from Springer Verlag. | تدمد: | 03642313 14322323 |
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| DOI: | 10.1007/s00268-018-4492-2 |