Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
| العنوان: | Synaptic vesicle protein 2A as a potential biomarker in synaptopathies |
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| المؤلفون: | Heurling, Kerstin, Ashton, Nicholas J, Leuzy, Antoine, Zimmer, Eduardo R, Blennow, Kaj, Zetterberg, Henrik, Eriksson, Jonas, Lubberink, Mark, Schöll, Michael |
| المصدر: | Molecular and Cellular Neuroscience. 97:34-42 |
| مصطلحات موضوعية: | Biomarkers, Position emission tomography, SV2A, Synaptopathies |
| الوصف: | Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382939 https://doi.org/10.1016/j.mcn.2019.02.001 https://uu.diva-portal.org/smash/get/diva2:1314037/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 10447431 10959327 |
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| DOI: | 10.1016/j.mcn.2019.02.001 |