Immunogenicity of the adjuvanted recombinant zoster vaccine: persistence and anamnestic response to additional doses administered 10 years after primary vaccination.
| العنوان: | Immunogenicity of the adjuvanted recombinant zoster vaccine: persistence and anamnestic response to additional doses administered 10 years after primary vaccination. |
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| المؤلفون: | Hastie, Andrew, Catteau, Grégory, Enemuo, Adaora, Mrkvan, Tomas, Salaun, Bruno, Volpe, Stephanie, Smetana, Jan, Rombo, Lars, Schwarz, Tino, Pauksen, Karlis, Hervé, Caroline, Bastidas, Adriana, Schuind, Anne |
| المصدر: | Journal of Infectious Diseases. 224(12):2025-2034 |
| مصطلحات موضوعية: | adjuvanted recombinant zoster vaccine, herpes zoster, persistence of immune response, safety |
| الوصف: | BACKGROUND: The adjuvanted recombinant zoster vaccine (RZV) is highly immunogenic and efficacious in adults ≥50 years (Y) of age (YOA). We evaluated (1) long-term immunogenicity of an initial 2-dose RZV schedule by following-up adults vaccinated at ≥60 YOA and by modeling, and (2) immunogenicity of 2 additional doses administered 10Y post-initial vaccination.METHODS: Persistence of humoral and cell-mediated immune (CMI) responses to 2 initial RZV doses was assessed through 10Y post-initial vaccination, and modeled through 20Y using a Piecewise, Power law and Fraser model. Immunogenicity and safety of 2 additional RZV doses were also evaluated (NCT02735915).RESULTS: Seventy adults were enrolled. Ten years post-initial vaccination, humoral and CMI responses were ~6-fold and ~3.5-fold above pre-initial vaccination levels, respectively. Predicted immune persistence through 20Y post-initial vaccination was similar across the 3 models. Sixty-two participants (82.6±4.4 YOA) received at least 1 additional RZV dose. Strong anamnestic humoral and CMI responses were elicited by 1 additional dose, without further increases after a second additional dose.CONCLUSIONS: Immune responses to an initial 2-dose RZV course persisted for many years in older adults. Strong anamnestic immune responses can be induced by additional dosing 10Y after the initial 2-dose course. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427103 https://doi.org/10.1093/infdis/jiaa300 https://uu.diva-portal.org/smash/get/diva2:1506462/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 00221899 15376613 |
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| DOI: | 10.1093/infdis/jiaa300 |