Cancer incidence in a male adult population in relation to estimated protracted colon dose - A nested case control study in Northern Sweden after the Chernobyl Nuclear Power Plant accident
| العنوان: | Cancer incidence in a male adult population in relation to estimated protracted colon dose - A nested case control study in Northern Sweden after the Chernobyl Nuclear Power Plant accident |
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| المؤلفون: | Tondel, Martin, Nordqvist, Tobias, Isaksson, Mats, Raaf, Christopher, Wålinder, Robert |
| المصدر: | Science of the Total Environment. 838 |
| مصطلحات موضوعية: | Dosimetry, Radiation, cancer incidence, Cohort, BEIR |
| الوصف: | Introduction: Uncertainty in the dose-response of low dose radiation raised concern of an increased cancer incidence in Sweden after the Chernobyl Nuclear Power Plant (NPP) accident. Material and methods: A closed cohort was created of all males >= 18 years of age living in the Northern Sweden in 1986. In total 826,400 individuals were enrolled including 40,874 hunters. A nested case-control design was used with five controls randomly selected for each cancer case matched on year of diagnosis and year of birth. Individual absorbed colon dose was calculated 1986 to 2015. Allowing for a 5-year latency period Hazard Ratios (HR) per mGy with 95% Confidence Intervals (95% CI) were calculated in a conditional logistic regression adjusted by rural/non-rural living, length of education and pre-Chernobyl cancer incidence 1980 to 1985. A total of 127,109 cancer cases occurred from 1 January 1991 to 31 December 2015. Cancer was classified in: 1) Organ-specific (stomach, colon, liver, lung, prostate, urinary bladder, thyroid and leukaemia), 2) Other and 3) Not previously associated to ionizing radiation. Results: The average colon dose in cases was 1.77 mGy compared to controls 1.73 mGy. Hunters average colon dose was 2.32 mGy. Organ-specific cancers showed the highest HR per mGy both in the full cohort, adj HR 1.019 (1.014-1.024) and the hunter subcohort, adj HR 1.014 (1.001-1.027) during follow-up 1991 to 2015. Other cancer and Not previously associated with ionizing radiation showed lower HR per mGy. Therefore, the adj HR per mGy for Total cancer, 1.013 (1.009-1.017) was explained by Organ-specific cancer. Increased adj HR per mGy was seen in stomach, colon and prostate cancer, respectively in the full cohort and lung cancer in hunters. Conclusions: Some cancer sites previously associated with ionizing radiation showed a positive adjusted HR per mGy both in the full cohort and in the hunter subcohort. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-479889 https://doi.org/10.1016/j.scitotenv.2022.156349 https://uu.diva-portal.org/smash/get/diva2:1680817/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 00489697 18791026 |
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| DOI: | 10.1016/j.scitotenv.2022.156349 |