The anti-inflammatory peptide Catestatin blocks chemotaxis
| العنوان: | The anti-inflammatory peptide Catestatin blocks chemotaxis |
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| المؤلفون: | Muntjewerff, Elke M., Parv, Kristel, Mahata, Sushil K., van Riessen, N. Koen, Phillipson, Mia, 1973, Christoffersson, Gustaf, van den Bogaart, Geert |
| المصدر: | Journal of Leukocyte Biology. 112(2):273-278 |
| مصطلحات موضوعية: | catestatin, chemotaxis, M phi s, migration, monocytes, neutrophil, pro-angiogenesis |
| الوصف: | Increased levels of the anti-inflammatory peptide Catestatin (CST), a cleavage product of the pro-hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (M phi s) in inflamed tissues. Here, it is reported that CST blocks leukocyte migration toward inflammatory chemokines. By in vitro and in vivo migration assays, it is shown that although CST itself is chemotactic, it blocks migration of monocytes and neutrophils to inflammatory attracting factor CC-chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 2 (CXCL2). Moreover, it directs CX(3)CR1(+) M phi s away from pancreatic islets. These findings suggest that the anti-inflammatory actions of CST are partly caused by its regulation of chemotaxis. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484555 https://doi.org/10.1002/JLB.3CRA1220-790RR https://uu.diva-portal.org/smash/get/diva2:1695718/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 07415400 |
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| DOI: | 10.1002/JLB.3CRA1220-790RR |