Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis
| العنوان: | Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis |
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| المؤلفون: | Li, Doudou, Lu, Ying, Yuan, Shuai, Cai, Xiaxia, He, Yuan, Chen, Jie, Wu, Qiong, He, Di, Fang, Aiping, Bo, Yacong, Song, Peige, Bogaert, Debby, Tsilidis, Kostas, Larsson, Susanna C., Yu, Huanling, Zhu, Huilian, Theodoratou, Evropi, Zhu, Yimin, Li, Xue |
| المصدر: | American Journal of Clinical Nutrition. 116(1):230-243 |
| مصطلحات موضوعية: | umbrella review, updated meta-analyses, trimethylamine-N-oxide, TMAO, all-cause mortality, cardiovascular disease, hypertension, diabetes mellitus |
| الوصف: | Background: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO concentrations are linked to a wide range of health outcomes.Objectives: This study aimed to summarize health outcomes related to circulating TMAO concentrations.Methods: We searched the Embase. Medline, Web of Science, and Scopus databases from inception to 15 February, 2022 to identify and update meta-analyses examining the associations between 'TAO and multiple health outcomes. For each health outcome, we estimated the summary effect size. 95% prediction CI. between-study heterogeneity. evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations.Results: This umbrella review identified 24 meta-analyses that investigated the association between circulating 'TAO concentrations and health outcomes including all-cause mortality, cardiovascular diseases (CVDs), diabetes mellitus (DM), cancer. and renal function. We updated these meta-analyses by including a total of 82 individual studies on 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found 6 (33%) associations (i.e., all-cause mortality, CVD mortality, major adverse cardiovascular events, hypertension. DM, and glomerular filtration rate) to present highly suggestive evidence.Conclusions: TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension. CVD, DM. cancer, and kidney function. Further studies are needed to investigate whether circulating 'MAO concentrations could be an intervention target for chronic disease. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485873 https://doi.org/10.1093/ajcn/nqac074 https://uu.diva-portal.org/smash/get/diva2:1700216/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 00029165 19383207 |
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| DOI: | 10.1093/ajcn/nqac074 |