TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
| العنوان: | TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours |
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| المؤلفون: | Kolnes, Anders Jensen, oystese, Kristin Astrid Berland, Sjöstedt, Evelina, Olarescu, Nicoleta Cristina, Heck, Ansgar, Pahnke, Jens, Dahlberg, Daniel, Berg-Johnsen, Jon, Ringstad, Geir, Casar Borota, Olivera, Bollerslev, Jens, Jorgensen, Anders Palmstrom |
| المصدر: | Pituitary. 26(2):227-236 |
| مصطلحات موضوعية: | Pituitary adenomas, Plasma gonadotropins, Tumour volume, Transforming growth factor beta receptor 3 like (TGFBR3L), Transforming growth factor beta receptor 3 (TGFBR3) |
| الوصف: | Purpose Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-terminal region. We aimed to characterize TGFBR3L detection in a well-characterized, prospectively collected cohort of non-functioning pituitary neuroendocrine tumours (NF-PitNETs) and correlate it to clinical data.Methods 144 patients operated for clinically NF-PitNETs were included. Clinical, radiological and biochemical data were recorded. Immunohistochemical (IHC) staining for FSH beta and LH beta was scored using the immunoreactive score (IRS), TGFBR3L and TGFBR3 were scored by the percentage of positive stained cells.Results TGFBR3L staining was selectively present in 52% of gonadotroph tumours. TGFBR3L was associated to IRS of LH beta (median 2 [IQR 0-3] in TGFBR3L negative and median 6 [IQR 3-9] in TGFBR3L positive tumours, p < 0.001), but not to the IRS of FSH beta (p = 0.32). The presence of TGFBR3L was negatively associated with plasma gonadotropin concentrations in males (P-FSH median 5.5 IU/L [IQR 2.9-9.6] and median 3.0 [IQR 1.8-5.6] in TGFBR3L negative and positive tumours respectively, p = 0.008) and P-LH (median 2.8 IU/L [IQR 1.9-3.7] and median 1.8 [IQR 1.1-3.0] in TGFBR3L negative and positive tumours respectively, p = 0.03). TGFBR3 stained positive in 22% (n = 25) of gonadotroph tumours with no correlation to TGFBR3L.Conclusion TGFBR3L was selectively detected in half (52%) of gonadotroph NF-PitNETs. The association to LH beta staining and plasma gonadotropins suggests that TGFBR3L may be involved in hormone production in gonadotroph NF-PitNETs. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512250 https://doi.org/10.1007/s11102-023-01310-x https://uu.diva-portal.org/smash/get/diva2:1800903/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
Find this article in full text from Springer Verlag. | تدمد: | 1386341X 15737403 |
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| DOI: | 10.1007/s11102-023-01310-x |