In this study, we assessed the overall risks that influence advanced care at home (ACH) patients enrolled in 8 municipalities in the western region of Sweden. We also conducted a medical assessment of a limited number of ACH cases based on the registered information from the university hospital in Gothenburg, with regard to survival after a disaster. Two different questionnaires were distributed, and the results were collected separately and analyzed using descriptive statistical analysis. The results indicate that there is a low level of preparedness among the health care service providers for addressing the needs of ACH patients following a major incident or disaster. For this group, the impact of a disaster depends on their vulnerability, specific diagnosis, the medical support required, and the duration of the incident or disaster.