التفاصيل البيبلوغرافية
| العنوان: |
Uterus transplantation: the science and clinical update |
| المؤلفون: |
Brännström, Mats, 1958, Boccio, M. V., Pittman, J. |
| المصدر: |
Current Opinion in Physiology. 13:49-54 |
| مصطلحات موضوعية: |
Obstetrics, Gynecology and Reproductive Medicine, Reproduktionsmedicin och gynekologi, deceased donor, female, female fertility, graft rejection, human, immunosuppressive treatment, live birth, living donor, minimally invasive surgery, nonhuman, preclinical study, reperfusion injury, Review, transplantation, uterus surgery, vein blood flow |
| الوصف: |
Purpose of review: The aim of uterus transplantation is to treat uterine factor infertility, due to absence of a functional uterus. This review provides information on key research findings in the field of uterus transplantation. The animal-based preclinical uterus transplantation research started around 20 years back with systematic research in several animal species, including non-human primates. This research investigated important aspects such as surgery, immunosuppression, ischemia-reperfusion injury, rejection, and fertility. In 2013, the first clinical uterus transplantation trial started and this was a live donor trial including nine transplantations. The first live birth was reported in 2014 and this has been followed by several more births from the initial trial in Sweden but also from other trials. The published uterus transplantations procedures, both from live donors and deceased donors, will be reviewed in detail. Recent findings: The surgical procedures to harvest a uterus from a live or from a deceased donor have developed and minimal invasive techniques are being introduced in live donor surgery for uterus transplantation. Some modifications of anatomical sites of venous outflows have been introduced. The efficiency of the procedure, in terms of surgical success with viable grafts after one month, as well as the rate of successful transplantations, with live births as the primary endpoint, have proven to be high. Uterus transplantation is an experimental clinical procedure that is performed within clinical trials at many centers worldwide. The accumulated research data from these trials will pave the way for establishment of uterus transplantation as a safe and efficient procedure to treat uterine factor infertility. © 2019 Elsevier Ltd |
| URL الوصول: |
https://gup.ub.gu.se/publication/290780 |
| قاعدة البيانات: |
SwePub |
