التفاصيل البيبلوغرافية
| العنوان: |
Gap junction coupling and islet delta-cell function in health and disease |
| المؤلفون: |
Miranda, Caroline, Begum, Manisha, Vergari, E., Briant, L. J. B. |
| المصدر: |
Peptides. 147(January) |
| مصطلحات موضوعية: |
Clinical Medicine, Klinisk medicin, Gap junction, Glucagon, Insulin, Islet, Paracrine, Somatostatin |
| الوصف: |
The pancreatic islets contain beta-cells and alpha-cells, which are responsible for secreting two principal gluco-regulatory hormones; insulin and glucagon, respectively. However, they also contain delta-cells, a relatively sparse cell type that secretes somatostatin (SST). These cells have a complex morphology allowing them to establish an extensive communication network throughout the islet, despite their scarcity. Delta-cells are electrically excitable cells, and SST secretion is released in a glucose- and KATP-dependent manner. SST hyperpolarises the alpha-cell membrane and suppresses exocytosis. In this way, islet SST potently inhibits glucagon release. Recent studies investigating the activity of delta-cells have revealed they are electrically coupled to beta-cells via gap junctions, suggesting the delta-cell is more than just a paracrine inhibitor. In this Review, we summarize delta-cell morphology, function, and the role of SST signalling for regulating islet hormonal output. A distinguishing feature of this Review is that we attempt to use the discovery of this gap junction pathway, together with what is already known about delta-cells, to reframe the role of these cells in both health and disease. In particular, we argue that the discovery of gap junction communication between delta-cells and beta-cells provides new insights into the contribution of delta-cells to the islet hormonal defects observed in both type 1 and type 2 diabetes. This reappraisal of the delta-cell is important as it may offer novel insights into how the physiology of this cell can be utilised to restore islet function in diabetes. © 2021 Elsevier Inc. |
| URL الوصول: |
https://gup.ub.gu.se/publication/313556 |
| قاعدة البيانات: |
SwePub |
