التفاصيل البيبلوغرافية
| العنوان: |
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting |
| المؤلفون: |
Anttila, V., Saraste, A., Knuuti, J., Hedman, M., Jaakkola, P., Laugwitz, K. L., Krane, M., Jeppsson, Anders, 1960, Sillanmäki, S., Rosenmeier, J., Zingmark, P., Rudvik, A., Garkaviy, P., Watson, C., Pangalos, M. N., Chien, K. R., Fritsche-Danielson, R., Collén, A., Gan, Li-Ming, 1969 |
| المصدر: |
Molecular Therapy. 31(3):866-874 |
| مصطلحات موضوعية: |
Clinical Medicine, Klinisk medicin, CABG, cardiac, clinical trial, EPICCURE, LVEF, mRNA, phase 2a, regeneration, safety, therapeutic mRNA, tolerability, VEGF-A |
| الوصف: |
Vascular endothelial growth factor A (VEGF-A) has therapeutic cardiovascular effects, but delivery challenges have impeded clinical development. We report the first clinical study of naked mRNA encoding VEGF-A (AZD8601) injected into the human heart. EPICCURE (ClinicalTrials.gov: NCT03370887) was a randomized, double-blind study of AZD8601 in patients with left ventricular ejection fraction (LVEF) 30%–50% who were undergoing elective coronary artery bypass surgery. Thirty epicardial injections of AZD8601 (total 3 mg) or placebo in citrate-buffered saline were targeted to ischemic but viable myocardial regions mapped using quantitative [15O]-water positron emission tomography. Seven patients received AZD8601 and four received placebo and were followed for 6 months. There were no deaths or treatment-related serious adverse events and no AZD8601-associated infections, immune reactions, or arrhythmias. Exploratory outcomes indicated potential improvement in LVEF, Kansas City Cardiomyopathy Questionnaire scores, and N-terminal pro-B-type natriuretic peptide levels, but the study is limited in size, and significant efficacy conclusions are not possible from the dataset. Naked mRNA without lipid encapsulation may provide a safe delivery platform for introducing genetic material to cardiac muscle, but further studies are needed to confirm efficacy and safety in a larger patient pool. © 2022 |
| URL الوصول: |
https://gup.ub.gu.se/publication/324487 |
| قاعدة البيانات: |
SwePub |
