Optimizing clinical O2 saturation mapping using hyperspectral imaging and diffuse reflectance spectroscopy in the context of epinephrine injection

التفاصيل البيبلوغرافية
العنوان: Optimizing clinical O2 saturation mapping using hyperspectral imaging and diffuse reflectance spectroscopy in the context of epinephrine injection
المؤلفون: Gustafsson, Nils, Bunke, Josefine, Magnusson, Ludvig, Albinsson, John, Hérnandez-Palacios, Julio, Sheikh, Rafi, Malmsjö, Malin, Merdasa, Aboma
المصدر: Biomed. Opt. Express NanoLund: Centre for Nanoscience. 15(3):1995-2013
مصطلحات موضوعية: Absorption spectroscopy, Clinical applications, Diffuse optical spectroscopy, Diffuse reflectance, Hyperspectral imaging, Spectral linewidth, Teknik, Medicinteknik, Medicinsk laboratorie- och mätteknik, Engineering and Technology, Medical Engineering, Medical Laboratory and Measurements Technologies
الوصف: Clinical determination of oxygen saturation (sO2) in patients is commonly performed via non-invasive optical techniques. However, reliance on a few wavelengths and some form of pre-determined calibration introduces limits to how these methods can be used. One example involves the assessment of sO2 after injection of local anesthetic using epinephrine, where some controversy exists around the time it takes for the epinephrine to have an effect. This is likely caused by a change in the tissue environment not accounted for by standard calibrated instruments and conventional analysis techniques. The present study aims to account for this changing environment by acquiring absorption spectra using hyperspectral imaging (HSI) and diffuse reflectance spectroscopy (DRS) before, during, and after the injection of local anesthesia containing epinephrine in human volunteers. We demonstrate the need to account for multiple absorbing species when applying linear spectral unmixing in order to obtain more clinically relevant sO2 values. In particular, we demonstrate how the inclusion of water absorption greatly affects the rate at which sO2 seemingly drops, which in turn sheds light on the current debate regarding the time required for local anesthesia with epinephrine to have an effect. In general, this work provides important insight into how spectral analysis methods need to be adapted to specific clinical scenarios to more accurately assess sO2.
URL الوصول: https://lup.lub.lu.se/record/5f860672-be91-4164-b2b3-bfc8f17164c6
http://dx.doi.org/10.1364/BOE.506492
قاعدة البيانات: SwePub
الوصف
تدمد:21567085
DOI:10.1364/BOE.506492