Metabolic remission precedes possible weight regain after gastric bypass surgery
| العنوان: | Metabolic remission precedes possible weight regain after gastric bypass surgery |
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| المؤلفون: | Rogova, Oksana, Herzog, Katharina, Al-Majdoub, Mahmoud, Miskelly, Michael, Lindqvist, Andreas, Bennet, Louise, Hedenbro, Jan L, Wierup, Nils, Spégel, Peter |
| المصدر: | Obesity EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health. 31(10):2530-2542 |
| مصطلحات موضوعية: | Medicin och hälsovetenskap, Klinisk medicin, Kirurgi, Medical and Health Sciences, Clinical Medicine, Surgery |
| الوصف: | OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study involving 148 patients before RYGB and at 2, 12, and 60 months post RYGB. Both short-term and long-term alterations in metabolism were assessed. Anthropometric and clinical variables were assessed at all study visits.RESULTS: This study found that the vast majority of changes in metabolite levels occurred during the first 2 months post RYGB. Notably, thereafter the metabolome started to return toward the presurgical state. Consequently, a close-to-presurgical metabolome was observed at the time when patients reached their lowest weight and glucose level. Lipids with longer acyl chains and a higher degree of unsaturation were altered more dramatically compared with shorter and more saturated lipids, suggesting a systematic and reversible lipid remodeling.CONCLUSIONS: Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration. |
| URL الوصول: | https://lup.lub.lu.se/record/b2d68ee1-b28e-4120-ada4-4917fd305951 https://onlinelibrary.wiley.com/doi/10.1002/oby.23864 http://dx.doi.org/10.1002/oby.23864 |
| قاعدة البيانات: | SwePub |
| تدمد: | 1930739X |
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| DOI: | 10.1002/oby.23864 |