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Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

التفاصيل البيبلوغرافية
العنوان: Human iPSC-Derived Hippocampal Spheroids : An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
المؤلفون: Pomeshchik, Yuriy, Klementieva, Oxana, Gil, Jeovanis, Martinsson, Isak, Hansen, Marita Grønning, de Vries, Tessa, Sancho-Balsells, Anna, Russ, Kaspar, Savchenko, Ekaterina, Collin, Anna, Vaz, Ana Rita, Bagnoli, Silvia, Nacmias, Benedetta, Rampon, Claire, Sorbi, Sandro, Brites, Dora, Marko-Varga, György, Kokaia, Zaal, Rezeli, Melinda, Gouras, Gunnar K., Roybon, Laurent
المصدر: Stem Cell Reports StemTherapy: National Initiative on Stem Cells for Regenerative Therapy MultiPark: Multidisciplinary research focused on Parkinson´s disease NanoLund: Centre for Nanoscience. 15(1):256-273
مصطلحات موضوعية: Alzheimer disease, hippocampus, iPSC, NeuroD1, protein aggregation, proteomics, spheroids, transcriptomics, viral-mediated gene therapy, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Neurovetenskaper, Medical and Health Sciences, Basic Medicine, Neurosciences, Cell- och molekylärbiologi, Cell and Molecular Biology
الوصف: In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.
URL الوصول: https://lup.lub.lu.se/record/fd37f0d1-d452-414a-ba0c-38b395cdbffc
http://dx.doi.org/10.1016/j.stemcr.2020.06.001
قاعدة البيانات: SwePub
الوصف
تدمد:22136711
DOI:10.1016/j.stemcr.2020.06.001