| المساهمون: |
Kuru, Ogul Can (VerfasserIn); Netkueakul, Woranan (VerfasserIn); Pelin, Marco (VerfasserIn); Keshavan, Sandeep (VerfasserIn); Song, Zhengmei (VerfasserIn); Ma, Baojin (VerfasserIn); Gómes, Julio (VerfasserIn); Abalos, Elvira Villaro (VerfasserIn); de Luna, Luis Augusto Visani (VerfasserIn); Loret, Thomas (VerfasserIn); Fordham, Alexander (VerfasserIn); Drummond, Matthew (VerfasserIn); Kontis, Nikolaos (VerfasserIn); Anagnostopoulos, George (VerfasserIn); Paterakis, George (VerfasserIn); Cataldi, Pietro (VerfasserIn); Tubaro, Aurelia (VerfasserIn); Galiotis, Costas (VerfasserIn); Kinloch, Ian (VerfasserIn); Fadeel, Bengt (VerfasserIn); Bussy, Cyrill (VerfasserIn); Kostarelos, Kostas (VerfasserIn); Buerki-Thurnherr, Tina (VerfasserIn); Prato, Maurizio (VerfasserIn); Bianco, Alberto (VerfasserIn); Wick, Peter (VerfasserIn) |
| مستخلص: |
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years in terms of safety assessment. However, limited information is available concerning the hazard potential of GRM-containing products. In the present study, we conducted a comprehensive investigation of the potential biological effects of particles released through an abrasion process from reduced graphene oxide (rGO)-reinforced composites of polyamide 6 (PA6), in comparison to as-produced rGO. Limited responses to PA6-rGO exposure were found in the different invitro models representing potential affected organs. Only as-produced rGO induced substantial adverse effects, in particular in macrophages. Since inhalation of airborne materials is a key concern, we assessed adverse effects in vivo . To this end, the response at upto 28 days after a single pulmonary exposure was evaluated in mice. In agreement with the invitro data, PA6-rGO induced a modest and transient pulmonary inflammation, resolved by day 28. In contrast, rGO induced a longer-lasting, albeit moderate inflammation that did not lead to tissue remodeling within 28 days. Taken together, the present study suggests a negligible impact on human health under acute exposure conditions of GRM fillers such as rGO when released from composites at doses expected at the workplace |
