دورية أكاديمية
Memory Disrupting Effects of Nonmuscle Myosin II Inhibition Depend on the Class of Abused Drug and Brain Region
| العنوان: | Memory Disrupting Effects of Nonmuscle Myosin II Inhibition Depend on the Class of Abused Drug and Brain Region |
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| اللغة: | English |
| المؤلفون: | Briggs, Sherri B., Blouin, Ashley M., Young, Erica J., Rumbaugh, Gavin, Miller, Courtney A. |
| المصدر: | Learning & Memory. Feb 2017 24(2):70-75. |
| الإتاحة: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Peer Reviewed: | Y |
| Page Count: | 6 |
| تاريخ النشر: | 2017 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Memory, Brain Hemisphere Functions, Brain, Inhibition, Drug Abuse, Stimulants, Cocaine, Narcotics, Pathology |
| DOI: | 10.1101/lm.043976.116 |
| تدمد: | 1072-0502 |
| مستخلص: | Depolymerizing actin in the amygdala through nonmuscle myosin II inhibition (NMIIi) produces a selective, lasting, and retrieval-independent disruption of the storage of methamphetamine-associated memories. Here we report a similar disruption of memories associated with amphetamine, but not cocaine or morphine, by NMIIi. Reconsolidation appeared to be disrupted with cocaine. Unlike in the amygdala, methamphetamine-associated memory storage was not disrupted by NMIIi in the hippocampus, nucleus accumbens, or orbitofrontal cortex. NMIIi in the hippocampus did appear to disrupt reconsolidation. Identification of the unique mechanisms responsible for NMII-mediated, amygdala-dependent disruption of memory storage associated with the amphetamine class may enable induction of retrieval-independent vulnerability to other pathological memories. |
| Abstractor: | As Provided |
| Entry Date: | 2017 |
| رقم الأكسشن: | EJ1126611 |
| قاعدة البيانات: | ERIC |
| تدمد: | 1072-0502 |
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| DOI: | 10.1101/lm.043976.116 |