دورية أكاديمية
ß-Adrenoceptor Activation Enhances L-Type Calcium Channel Currents in Anterior Piriform Cortex Pyramidal Cells of Neonatal Mice: Implication for Odor Learning
| العنوان: | ß-Adrenoceptor Activation Enhances L-Type Calcium Channel Currents in Anterior Piriform Cortex Pyramidal Cells of Neonatal Mice: Implication for Odor Learning |
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| اللغة: | English |
| المؤلفون: | Ghosh, Abhinaba, Mukherjee, Bandhan, Chen, Xihua, Yuan, Qi |
| المصدر: | Learning & Memory. Mar 2017 24(3):132-135. |
| الإتاحة: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Peer Reviewed: | Y |
| Page Count: | 4 |
| تاريخ النشر: | 2017 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Olfactory Perception, Preferences, Learning Modalities, Brain, Animals, Stimuli |
| DOI: | 10.1101/lm.044818.116 |
| تدمد: | 1072-0502 |
| مستخلص: | Early odor preference learning occurs in one-week-old rodents when a novel odor is paired with a tactile stimulation mimicking maternal care. ß-Adrenoceptors and L-type calcium channels (LTCCs) in the anterior piriform cortex (aPC) are critically involved in this learning. However, whether ß-adrenoceptors interact directly with LTCCs in aPC pyramidal cells is unknown. Here we show that pyramidal cells expressed significant LTCC currents that declined with age. ß-Adrenoceptor activation via isoproterenol age-dependently enhanced LTCC currents. Nifedipine-sensitive, isoproterenol enhancement of calcium currents was only observed in post-natal day 7-10 mice. APC ß-adrenoceptor activation induced early odor preference learning was blocked by nifedipine coinfusion. |
| Abstractor: | As Provided |
| Entry Date: | 2017 |
| رقم الأكسشن: | EJ1131264 |
| قاعدة البيانات: | ERIC |
| تدمد: | 1072-0502 |
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| DOI: | 10.1101/lm.044818.116 |