دورية أكاديمية
An In-Laboratory Stressor Reveals Unique Genetic Variation in Child Cortisol Output
| العنوان: | An In-Laboratory Stressor Reveals Unique Genetic Variation in Child Cortisol Output |
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| اللغة: | English |
| المؤلفون: | Raffington, Laurel (ORCID |
| المصدر: | Developmental Psychology. Oct 2022 58(10):1832-1848. |
| الإتاحة: | American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org |
| Peer Reviewed: | Y |
| Page Count: | 17 |
| تاريخ النشر: | 2022 |
| Sponsoring Agency: | National Institutes of Health (NIH) (DHHS) |
| Contract Number: | R01HD083613 R01HD092548 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Twins, Genetics, Stress Variables, Biochemistry, Physiology, Environmental Influences, Children, Adolescents, Measurement, Longitudinal Studies |
| مصطلحات جغرافية: | Texas |
| DOI: | 10.1037/dev0001393 |
| تدمد: | 0012-1649 1939-0599 |
| مستخلص: | Dysregulation of biological stress response, as measured by cortisol output, has been a primary candidate mechanism for how social experiences become biologically embedded. Cortisol is the primary output of the hypothalamic pituitary adrenal (HPA) axis. Cortisol levels vary systematically across the day and change in response to both sudden, acute stress experiences as well as prolonged exposure to environmental stress. Using data from 8- to 15-year-old twins in the Texas Twin Project, we investigate the extent to which genetic influences are shared across different measures of cortisol output: chronic cortisol accumulations in hair (n = 1,104), diurnal variation in salivary output (n = 488), and salivary response to a standardized, acute in-laboratory stressor (n = 537). Multivariate twin models indicate that genetic factors regulating cortisol response to the in-laboratory stressor are separable from those regulating baseline cortisol levels, naturally occurring diurnal variation in cortisol, and hair cortisol levels. These findings illustrate that novel environments can reveal unique genetic variation, reordering people in terms of their observed phenotype rather than only magnifying or mitigating preexisting differences. |
| Abstractor: | As Provided |
| Entry Date: | 2023 |
| رقم الأكسشن: | EJ1366919 |
| قاعدة البيانات: | ERIC |
| تدمد: | 0012-1649 1939-0599 |
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| DOI: | 10.1037/dev0001393 |