دورية أكاديمية
Central Synaptic Mechanisms Underlie Short-Term Olfactory Habituation in 'Drosophila' Larvae
| العنوان: | Central Synaptic Mechanisms Underlie Short-Term Olfactory Habituation in 'Drosophila' Larvae |
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| اللغة: | English |
| المؤلفون: | Larkin, Aoife, Karak, Somdatta, Priya, Rashi |
| المصدر: | Learning & Memory. Dec 2010 17(12):645-653. |
| الإتاحة: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
| Peer Reviewed: | Y |
| وصف مادي: | |
| Page Count: | 9 |
| تاريخ النشر: | 2010 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Habituation, Brain Hemisphere Functions, Inhibition, Entomology, Olfactory Perception, Models, Neurological Organization |
| DOI: | 10.1101/lm.1839010 |
| تدمد: | 1072-0502 |
| مستخلص: | Naive "Drosophila" larvae show vigorous chemotaxis toward many odorants including ethyl acetate (EA). Chemotaxis toward EA is substantially reduced after a 5-min pre-exposure to the odorant and recovers with a half-time of [image omitted]20 min. An analogous behavioral decrement can be induced without odorant-receptor activation through channelrhodopsin-based, direct photoexcitation of odorant sensory neurons (OSNs). The neural mechanism of short-term habituation (STH) requires the (1) "rutabaga" adenylate cyclase; (2) transmitter release from predominantly GABAergic local interneurons (LNs); (3) GABA-A receptor function in projection neurons (PNs) that receive excitatory inputs from OSNs; and (4) NMDA-receptor function in PNs. These features of STH cannot be explained by simple sensory adaptation and, instead, point to plasticity of olfactory synapses in the antennal lobe as the underlying mechanism. Our observations suggest a model in which NMDAR-dependent depression of the OSN-PN synapse and/or NMDAR-dependent facilitation of inhibitory transmission from LNs to PNs contributes substantially to short-term habituation. |
| Abstractor: | As Provided |
| Entry Date: | 2011 |
| رقم الأكسشن: | EJ910258 |
| قاعدة البيانات: | ERIC |
| تدمد: | 1072-0502 |
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| DOI: | 10.1101/lm.1839010 |